26
1
60
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T1767 | BMH-21 | BMH21 | DNA/RNA Synthesis |
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. | |||
T14141 | AGI-24512 | Others , Methionine Adenosyltransferase (MAT) | |
AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro. | |||
T7318 | Elimusertib | BAY-1895344 | ATM/ATR |
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... | |||
T23974 | DDRI-18 | DDRI18,DDRI 18 | DNA/RNA Synthesis |
DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica... | |||
T23284 | Ryuvidine | Histone Demethylase , Histone Methyltransferase , CDK | |
Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and inhibition of CDK4, and can be used to study breast cancer ... | |||
T9849 | HQ461 | CDK , Molecular Glues | |
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. | |||
T23095 | NU 9056 | NU9056 | Histone Acetyltransferase |
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines. | |||
T37450 | SSK1 | p38 MAPK | |
SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in... | |||
T26872 | BMVC4 | BMVC 4,BMVC-4 | |
BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity. | |||
T10557 | BLM-IN-1 | Others | |
BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arrest in cancer cells | |||
T39795 | Tricarbonyldichlororuthenium(II) dimer | CORM-2 | |
Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and ... | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d... | |||
T36704 | CCT241533 dihydrochloride | CCT 241533 dihydrochloride | |
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi... | |||
T78077 | E235 | Others | |
E235, an activator of the transcription factor 4 (ATF4), enhances the integrated stress response (ISR) and DNA damage response, thereby reducing cell viability and exhibiting anti-proliferative effects useful in tumor re... | |||
T78959 | ATR-IN-23 | ATM/ATR | |
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ... | |||
T73299 | APE1-IN-2 | Apoptosis | |
APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellul... | |||
T60478 | BTX161 | ||
BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabi... | |||
T81640 | NSC15520 | ||
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he... | |||
T37729 | IMP-1700 | ||
IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibit... | |||
T78715 | MS78 | ||
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while conc... | |||
T73558 | W1131 | ||
W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PD... | |||
T36934 | PK7242 (maleate) | PK7242 (maleate) | |
The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further prolife... | |||
T80847 | W1131 TFA | STAT | |
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc... | |||
T64022 | Antitumor agent-37 | ||
Antitumor agent-37 exhibits potent anti-proliferative and anti-metastatic effects. antitumor agent-37 induces severe DNA damage, leading to high expression of γ-H2AX and p53. antitumor agent-37 induces apoptosis by explo... | |||
T62651 | ATR-IN-11 | ||
ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinases. ATR-IN-11 is a promising lead compound for the discovery of subsequent drugs targeting the ATR kinase, a key regulator... | |||
T74393 | Antitumor agent-36 | ||
Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochond... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2915 | Bardoxolone | RTA 401,CDDO | Others , Nrf2 |
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-00700 | GADD45B Protein, Human, Recombinant (His) | Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of g... | |||
TMPY-02953 | TEM8/ANTXR1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser... | |||
TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... | |||
TMPY-04376 | PLK1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ... | |||
TMPH-01351 | FOxM1 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t... | |||
TMPH-01350 | FOxM1 Protein, Human, Recombinant (GST) | Human | E. coli |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t... | |||
TMPY-04681 | CHEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ... | |||
TMPY-04435 | CHEK2 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ... | |||
TMPH-01882 | PARP9 Protein, Human, Recombinant (His) | Human | E. coli |
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase ... | |||
TMPH-00646 | LexA repressor Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA int... | |||
TMPY-02527 | P53R2 Protein, Human, Recombinant (His) | Human | E. coli |
Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase... | |||
TMPJ-00870 | NCK1 Protein, Human, Recombinant (His) | Human | E. coli |
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ... | |||
TMPH-02930 | TREX1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f... | |||
TMPH-02201 | TREX1 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus |
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f... | |||
TMPY-04267 | MSH2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind... | |||
TMPY-00648 | UNC5A Protein, Human, Recombinant (hFc) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPY-00999 | UNC5A Protein, Human, Recombinant (His) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPY-02421 | PARP3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp... | |||
TMPY-04368 | Chk1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... | |||
TMPY-04433 | Chk1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... | |||
TMPH-01552 | IRF1 Protein, Human, Recombinant (GST & His) | Human | Baculovirus |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,... | |||
TMPY-02228 | P53 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and... | |||
TMPH-01734 | METTL3 Protein, Human, Recombinant (His) | Human | E. coli |
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of emb... | |||
TMPJ-00661 | PDCD5 Protein, Human, Recombinant (His) | Human | E. coli |
Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosi... | |||
TMPH-01273 | TRIP12 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a... | |||
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... | |||
TMPH-01880 | PARP2 Protein, Human, Recombinant (His) | Human | E. coli |
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is t... | |||
TMPH-01694 | MLKL Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... | |||
TMPY-04550 | JNK2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm... | |||
TMPY-02465 | PARP Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... | |||
TMPH-00849 | PSMD14 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus |
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded o... | |||
TMPH-02314 | XRCC5 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPY-00924 | SMAC Protein, Human, Recombinant (His) | Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p... | |||
TMPH-02315 | XRCC5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPH-01329 | FBXW7 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho... | |||
TMPY-04438 | PLK1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ... | |||
TMPH-01621 | BRCC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes... | |||
TMPY-06954 | SIRT5 Protein, Human, Recombinant (His) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPY-05241 | SIRT5 Protein, Human, Recombinant (Flag) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPH-01832 | Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His) | HPV 16 | E. coli |
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ... | |||
TMPY-04751 | VRK1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me... | |||
TMPH-01900 | DDX5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r... | |||
TMPH-01833 | Human Papilloma Virus type 16 (HPV 16) Protein E6 (His) | HPV 16 | Yeast |
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ... | |||
TMPY-04560 | VRK1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me... | |||
TMPH-02286 | USP7 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M... | |||
TMPY-05252 | Myeloperoxidase/MPO Protein, Human, Recombinant (His) | Human | HEK293 |
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important en... | |||
TMPH-01556 | EIF2AK2 Protein, Human, Recombinant (His) | Human | Yeast |
IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to v... | |||
TMPH-02877 | RIPK3 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggere... | |||
TMPH-02630 | MDM2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ... | |||
TMPH-00839 | RIPK3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggere... | |||
------------------------ More ------------------------ |